Objective.Depression has been associated with increased cardiovascular disease risk, and a depression-related elevation of high sensitivity C-reactive protein (hs-CRP) has been proposed as a possible mechanism.The objective of this paper is to examine association between depression and high sensitivity C-reactive protein (hs-CRP).Methods.Subjects consisted of 508 healthy adults (mean age 48.
5 years; 49% women, 88% white) residing in central Massachusetts.Data were collected at baseline and at quarterly intervals over a one-year period per individual.Multivariable linear mixed models were Sump Hose Assembly used to assess the association for the entire sample and by gender.Results.The mean Beck Depression Inventory score was 5.
8 (standard deviation (SD) 5.4; median 4.3), and average serum hs-CRP was 1.8 mg/L (SD 1.7; median 1.
2).Results from the multivariable linear mixed models show that individuals with higher depression scores have higher levels of hs-CRP.Analyses by gender show persistence of an independent association among women, but not among Accent Cabinet men.Body mass index (BMI = weight(kg)/height(m)2) appears to be a partial mediator of this relationship.Conclusion.
Depression score was correlated to hs-CRP levels in women.Further studies are required to elucidate the biological mechanisms underlying these associations and their implications.